UPCOMING EVENTS: GENETIC TESTS AND GUT MICROBIOME – 9 SEPTEMBER 2024

UPCOMING EVENTS: GENETIC TESTS AND GUT MICROBIOME – 9 SEPTEMBER

MyDetox Liver Detoxification Genetic Test | Overgenes
MyDetox genetic test

Genetic analysis of liver detoxification capacity

MyDetox assesses the genetic markers associated with the liver’s Phase I and Phase II enzymes to determine, on a personalized basis, the capacity to metabolize substances and drugs.

Overgenes MyDetox liver detoxification genetic test
Non-invasive Saliva sample, painless and suitable for any age
Once in a lifetime Your genetics don’t change: the analysis is performed only once
20 days Results available within 20 business days after the sample is received at the lab
Liver detoxification

What is liver detoxification and why does your genetics matter?

Liver detoxification is the liver’s ability to neutralize toxic substances coming from the environment, diet, medications or the body’s own metabolism.

This process takes place in two distinct phases. Individual genetics directly affects the efficiency of the enzymes involved in both phases, which determines how each person breaks down and eliminates toxic substances and drugs.

What is MyDetox for?

  • Analyze the genetic variants involved in the enzymes that transform toxic substances for elimination
  • Determine, on a personalized basis, the liver’s capacity in response to food and drugs
  • Provide useful information to personalize diet and prevent adverse responses
  • Guide clinical decisions on drug metabolization
Detoxification phases

Two phases, one complete enzymatic system

The liver processes toxins in two sequential phases. MyDetox assesses the genetic variants of the enzymes involved in both, determining the individual efficiency of each one.

Phase I · Transformation

Breakdown of toxins

Phase I enzymes — mainly the cytochrome P450 (CYP) family — break down toxic substances through oxidation, reduction and hydrolysis reactions. This phase transforms the original compounds into intermediate metabolites, which can be more reactive and need to be processed by Phase II.

Phase II · Conjugation and elimination

Solubilization and excretion

Phase II enzymes — such as glutathione transferases (GST), UDP-glucuronosyltransferases (UGT), N-acetyltransferases (NAT) and sulfotransferases (SULT) — conjugate the intermediate metabolites with molecules that make them water-soluble, allowing their elimination from the body through urine or bile.

Diagram of the liver detoxification process: Phase I (transformation), Intermediate Phase (oxidative stress) and Phase II (conjugation and elimination)
Indication

Who is MyDetox aimed at?

MyDetox is aimed at healthcare professionals who want to understand how their patients metabolize food and medications, with the aim of personalizing diet and preventing adverse drug responses.

Clinical applications

  • Personalization of diet based on individual detoxification capacity
  • Prevention of adverse drug reactions
  • Assessment of the patient’s liver enzymatic efficiency
  • Support for pharmacological prescription decisions
  • Identification of slow, normal or rapid metabolizers
+50 genes analyzed

Genes involved in liver detoxification

MyDetox analyzes genetic variants of more than 50 genes grouped into four functional blocks: Phase I, Intermediate Phase, Phase II and transport genes.

Phase I · Cytochrome P450

20 genes · Transformation enzymes
  • CYP1A1
  • CYP1A2
  • CYP1B1
  • CYP2A6
  • CYP2B6
  • CYP2C8
  • CYP2C9
  • CYP2C19
  • CYP2D6
  • CYP2E1
  • CYP3A4
  • CYP3A5
  • CYP3A7
  • CYP4B1
  • CYP4F2
  • TBXAS1 (CYP5A1)
  • CYP19A1
  • PTGIS (CYP8A1)
  • FMO1
  • POR (CYPOR)

Intermediate Phase

7 genes · Oxidative stress
  • CAT
  • CDA
  • DPYD
  • G6PD
  • OGG1
  • SOD1
  • MNSOD (SOD2)

Phase II · Conjugation

21 genes · Solubilization and elimination
  • NAT1 · Acetylation
  • NAT2 · Acetylation
  • UGT1A1
  • UGT1A3
  • UGT1A4
  • UGT1A7
  • UGT1A8
  • UGT1A9
  • UGT1A10
  • UGT2B7
  • UGT2B15
  • GSTM1
  • GSTM3
  • GSTP1
  • GSTT1
  • COMT
  • MTHFR
  • TPMT
  • NUDT15
  • SULT1A1
  • SULT1A2

Transport

4 genes · Substance transport
  • APOE
  • CFTR
  • SLC15A2
  • SLCO1B1
+50 genes analyzed involved in liver detoxification
How it works

From DNA to a personalized detoxification profile

A simple, non-invasive process designed for clinical practice.

Sample collection

Saliva sample following the kit instructions. Painless, with no prior preparation required.

Genetic analysis

Variants of more than 50 genes involved in Phase I and Phase II enzymes are analyzed.

Personalized report

Results by gene and by phase, with an indication of individual enzymatic efficiency.

Professional interpretation

The report is interpreted with a doctor or healthcare professional to guide clinical decisions.

MyDetox Report

Genetic liver detoxification profile

The report presents the analysis of each gene assessed, grouped by phase and enzymatic family, with indications on individual metabolic efficiency.

  • Analysis of variants by gene and their impact on enzymatic function
  • Grouped by Phase I (transformation) and Phase II (conjugation)
  • Identification of slow, normal and rapid metabolizers
  • Relevant information to personalize diet and pharmacological prescription
Content of the Overgenes MyDetox report Example results from the MyDetox genetic report
Frequently asked questions

Frequently asked questions about MyDetox

What is liver detoxification?

It is the liver’s ability to neutralize toxic substances from the environment or generated by the body. It takes place in two phases: in Phase I, toxins are broken down by enzymes of the cytochrome P450 family, and in Phase II they are conjugated with molecules that make them water-soluble for elimination.

What does MyDetox analyze?

It analyzes genetic variants of more than 50 genes involved in Phase I and Phase II liver detoxification enzymes. This includes the cytochrome P450 (CYP) family, glutathione transferases (GST), UDP-glucuronosyltransferases (UGT), N-acetyltransferases (NAT), sulfotransferases (SULT) and other genes relevant to transport and cellular protection.

Who is it aimed at?

At healthcare professionals who want to understand how their patients metabolize food and medications, with the aim of personalizing diet and avoiding adverse drug reactions.

What does it mean to be a slow, normal or rapid metabolizer?

Depending on the genetic variants present in each enzyme, a person may metabolize certain substances more slowly, normally, or more rapidly than average. This directly affects the effectiveness and safety of certain medications and the ability to eliminate toxins.

Is a medical prescription needed?

No prescription is needed, but it is recommended that the results be interpreted by a healthcare professional, especially regarding drug metabolization. Genetic information should be integrated with the patient’s clinical history.

Does the test need to be repeated over time?

No. The genetic profile doesn’t change throughout life, so the test is performed only once.

MyDetox · Overgenes

Discover your liver’s detoxification capacity

+50 genes analyzed to determine, on a personalized basis, how your body metabolizes substances, food and drugs.

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2 tests -25%
3 tests -30%
4 tests -35%
5+ tests -40%

* Descuento aplicable únicamente cuando todos los test genéticos del pedido corresponden a una misma persona.

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