Chronic inflammation
Identifies genetic variants that affect the tendency toward prolonged inflammatory responses. Persistent low-grade inflammation is a central mechanism in the development of chronic diseases.
- Pro-inflammatory cytokines: variants that increase baseline production of molecules such as IL-6, TNF-α and IL-1β
- Anti-inflammatory cytokines: IL-10 variants that can reduce the ability to control the inflammatory response
- Immune regulation: genetic balance between signals that activate and dampen inflammation